GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11734488 | 1 | rs4346698 | chr4:139119793 | SLC7A11 | chr4:139085248-139163503:- | 0.22 | 4.47 | 9.97E-6 | Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect) |
| THCA | cis | rs17401966 | 1 | rs4348727 | chr1:10265606 | KIF1B | chr1:10270764-10441659:+ | 0.2 | 6.11 | 2.03E-9 | Hepatocellular carcinoma |
| THCA | cis | rs438034 | 1 | rs435043 | chr1:214828812 | KCNK2 | chr1:215178885-215410435:+ | 0.17 | 3.58 | 0.000372 | Response to antineoplastic agents |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | ANKRD13B | chr17:27916801-27941778:+ | 0.36 | 8.9 | 1.2E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | CORO6 | chr17:27941774-27948441:- | 0.51 | 11.83 | 1.64E-28 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | EFCAB5 | chr17:28256874-28435469:+ | 0.59 | 11.17 | 6.8E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | GIT1 | chr17:27900487-27916610:- | 0.29 | 6.78 | 3.53E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | LRRC37B2 | chr17:28903483-28992715:+ | 0.17 | 3.78 | 0.000176 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | SSH2 | chr17:27952965-28257018:- | 0.37 | 8.34 | 7.97E-16 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | TP53I13 | chr17:27895739-27900174:+ | 0.21 | 5.6 | 3.54E-8 | Coffee consumption (cups per day) |
| THCA | cis | rs9790314 | 1 | rs4350933 | chr3:160955879 | NMD3 | chr3:160939099-160971319:+ | -0.11 | -3.59 | 0.000363 | Morning vs. evening chronotype |
| THCA | cis | rs12216499 | 1 | rs4351285 | chr6:159384673 | RSPH3 | chr6:159398268-159421198:- | 0.29 | 6.05 | 2.96E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs6494537 | 1 | rs4351999 | chr15:65992380 | DPP8 | chr15:65737999-65810035:- | -0.09 | -3.92 | 0.000103 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs4351999 | chr15:65992380 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.83 | 0.000148 | Mean corpuscular hemoglobin |
| THCA | cis | rs9783347 | 1 | rs4353250 | chr11:18323517 | GTF2H1 | chr11:18343816-18388590:+ | 0.37 | 9.94 | 2.7E-21 | Pancreatic cancer |